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Peptide/protein interactions with allergenic compounds

Chemicals causing contact allergy (haptens) interact with macromolecules (proteins) in the skin and form complexes that can elicit an immune response. Most haptens contain electrophilic sites that bind covalently to nucleophilic sites of a protein. Others, mainly hydroperoxides, form free radicals and are suggested to react with proteins via a radical mechanism.
Investigations of a radical mechanism involved in the formation of immunogenic hapten-protein complexes by hydroperoxides are performed.

Contact Information

Prof. Ann-Therese Karlberg

Dermatochemistry and Skin Allergy, Department of Chemistry, University of Gothenburg, SE-412 96 Gothenburg, Sweden

Visiting Address:
Kemigården 4 (Chalmers area), room 9015

Phone:
+46 (0)31 786 91 09

Contact Information

Anna Börje, PhD

Department of Chemistry, University of Gothenburg, SE-412 96 Gothenburg, Sweden

Visiting Address:
Kemigården 4 (Chalmers area), room 9012

Phone:
+46 (0)31 786 90 12

Page Manager: Martin Gillstedt|Last update: 1/3/2011
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